- Date: Friday, September 16, 2022
Match: Nsoatreman FC vs Bibiani GoldStars (ON TV)
Venue: Nana Amoah Koramansah II Park
Referee: Abdul Latiff Qadir Assistants: Alhassan Abdul Rauf and Mikaal-Il Fauzan 4th Referee: Emmanuel Otoo Match Commissioner: Yeboah Acheampong Venue Media Officer: Masawudu Issah
- Date: Saturday, September 17, 2022
Match: Dreams FC vs Kotoku Royals (ON TV)
Venue: Dawu Park
Referee: Julian Nunoo Assistants: Kwasi Acheampong Brobbey and Roland Addy 4th Referee: Maxwell Owusu Match Commissioner: Gabriel Inkoom Venue Media Officer: Delali Phrank Awutey
Match: Accra Lions vs Karela United
Venue: Accra Sports Stadium
Referee: Jacob Aduntera Assistants: Bawa Haruna and Sulemana Salau Deen 4th Referee: Andrews Awurisa Match Commissioner: James Amegatsey Venue Media Officer: Sena Richards GFA Cameraman: Emmanuel Osei
- Date: Sunday, September 18, 2022
Match: Hearts of Oak vs Great Olympics (ON TV)
Venue: Accra Sports Stadium
Referee: Edward Annan Assistants: Richard Nartey and David Addico 4th Referee: Franklin Akumatey Match Commissioner: Annan Lomotey Venue Media Officer: Sena Richards
Match: Medeama SC vs Real Tamale United
Venue: Akoon Park
Referee: Martins Akudzi Assistants: Seth Abletor and Theophilus Akugre 4th Referee: Laud Nettey Match Commissioner: Oduro Nyarko Venue Media Officer: Richard Baffour Nkrumah GFA Cameraman: Paul Egbenya
Match: Tamale City vs Legon Cities
Venue: Aliu Mahama Stadium
Referee: Clement Kwame Nkuah Assistants: Frederick Danful and Gilbert Adom Mensah 4th Referee: George Mawuli Vormawor Match Commissioner: Nana Boamah Darko Venue Media Officer: Muntaka Mohammed GFA Cameraman: Abdul Samed
- Date: Monday, September 19, 2022
Match: King Faisal vs Aduana FC (ON TV)
Venue: Baba Yara Stadium
Referee: Frederick Samena Assistants: Isaac Asante and Jasper Adenyo 4th Referee: Emmanuel Don Quansah Match Commissioner: Alhassan Seidu Venue Media Officer: Obed Acheampong GFA Cameraman: Emmanuel Osei
Match: FC Samartex vs Berekum Chelsea
Venue: Akoon Park
Referee: Eric Owusu Prempeh Assistants: Emmanuel Arkaifie and Alhassan Abdulai 4th Referee: Robert Musey Match Commissioner: Charles Darkwah Venue Media Officer: Richard Baffour Nkrumah GFA Cameraman: Emmanuel Lartey
Date: TBD
Match: Bechem United vs Asante Kotoko
Venue: Nana Fosu Gyeabour Park
Referee: Joseph Kwofie Assistants: Stephen Balanguena and Francis Bondzie Arthur 4th Referee: Jacob Assafuah Match Commissioner: Samuel Gyasi Venue Media Officer:
