Hearts of Oak stayed top and opened a two-point gap after beating Berekum Chelsea Sunday night.
Midfielder Benjamin Afutu scored first after 10 minutes in the Ghana Premier League match-day 27 fixture at the Accra Sports Stadium.
Kwadwo Obeng Jnr. scored his 8th of the campaign with a fine shot from distance to make it 2-0 in the 28th minute.
The Phobians held on to their two-goal lead until the final whistle.
Hearts of Oak have now amassed 49 points, two better than second-placed arch-rivals Asante Kotoko after 27 games.
Berekum Chelsea. meanwhile, stay 12th in the Ghana Premier League standings.
Watch match highlights: