Medeama SC failed to qualify for a Caf Confederation semi-final berth after a 1-0 defeat to Algerian giants MO Bejaia on Tuesday.
A 25-yard strike from Morgan Betrorangal beat Daniel Agyei in post and proved to be the match winner for the Algerians in the 52nd minute.
The Tarkwa-based side needed to avoid defeat to be able to amass nine points, but however, are out of the competition on head-to-head rule as both teams finished on eight points apiece.
Elsewhere, Young Africans of Tanzania were beaten by TP Mazembe in Congo by 3-1 to top group A with 13 points.
The Yellow and Mauves will now switch attention to the local league with two outstanding matches to clear.
They are 8th on the Ghana Premier league log with 34 points.